LGD-3033 vs LGD-4033: What Are the Differences?

LGD-3033 vs LGD-4033: Everything you need to know

Are you exploring the world of SARMs and trying to decide between LGD-3033 and LGD-4033? With so many options out there, it is overwhelming to choose the right one for your goals.

In this article, we will dive into the differences between LGD-3033 and LGD-4033, based on factual data and scientific research. So, if you're ready to make an informed decision, keep reading to discover the unique properties and benefits of each SARM.

Introduction to LGD-3033 and LGD-4033

LGD-3033 and LGD-4033 are both Selective Androgen Receptor Modulators (SARMs) that have gained popularity in the field of bodybuilding and performance enhancement. These compounds are known for their ability to improve muscle growth, increase strength, and aid in muscle recovery.

Both LGD-3033 and LGD-4033 have been shown to have minimal side effects when used responsibly. However, it's important to note that they may cause testosterone suppression, liver toxicity, and mood changes.

Overview of LGD-3033

LGD-3033 is a Selective Androgen Receptor Modulator (SARM) that is gaining popularity in the field of bodybuilding. It is known for its anabolic activity, meaning it promotes muscle growth and enhances performance without the androgenic side effects associated with traditional anabolic steroids.(1)

The chemical structure of LGD-3033 allows it to bind to the androgen receptors in the body, specifically targeting the muscles and bones. This selective binding leads to increased protein synthesis, resulting in accelerated muscle growth and improved bone density. Furthermore, LGD-3033 has been found to be effective in preventing muscle wasting, making it beneficial for those looking to maintain their muscle mass during periods of caloric deficit or when recovering from an injury.(2)

LGD-3033 is also known for its potential to enhance strength and endurance. Users report increased power output and improved performance during workouts. Additionally, LGD-3033 may aid in fat loss by boosting metabolism and increasing calorie expenditure.

Overall, LGD-3033 offers bodybuilders and athletes a safe and effective alternative to traditional steroids, with its anabolic benefits and minimal side effects. However, it is important to note that more research is needed to fully understand the long-term effects and potential risks associated with LGD-3033 use.

Overview of LGD-4033

LGD-4033, also known as Ligandrol,(3) is another Selective Androgen Receptor Modulator (SARM) that has gained popularity for  its ability to promote muscle mass and strength gains. This supplement also manages to give bodybuilders a powerful boost, but without the side effects typically associated with anabolic steroids.(4)

LGD-4033 works by selectively binding to the androgen receptors in the muscles and bones, stimulating protein synthesis and increasing muscle mass. It has a high affinity for androgen receptors in the muscles and shows minimal activity in other tissues, making it a favorable option for muscle growth.

The compound has been extensively researched and is safe when used in recommended dosages. It has been shown to be effective in increasing lean muscle mass, improving endurance, and enhancing recovery. LGD-4033 is often utilized by athletes and bodybuilders who aim to increase their strength and performance without the risks associated with traditional anabolic steroids.

Overall, LGD-4033 is a potent and promising compound for individuals looking to achieve significant muscle gains and improve their physical performance. Its mechanism of action and applications make it an attractive option in the field of bodybuilding.

LGD-3033 vs. LGD-4033 Effects and Benefits

When comparing the effects and benefits of LGD-3033 and LGD-4033, both compounds offer unique advantages in the field of bodybuilding.

It is advisable to consult with a healthcare professional or experienced bodybuilder to determine the most suitable compound for specific needs and to ensure safety and proper usage.

LGD-3033 Effects and Benefits

LGD-3033 is a Selective Androgen Receptor Modulator (SARM) that is known for its potential effects on muscle growth and performance enhancement. Some of the specific effects and benefits of LGD-3033 include:

  • Fat Loss: LGD-3033 has the potential to increase metabolism and promote fat loss, making it a popular compound among bodybuilders and athletes looking to improve body composition.
  • Increased Strength: Users of LGD-3033 often report significant strength gains, allowing them to lift heavier weights and perform better in their workouts.
  • Lean Muscle Gain: LGD-3033 is highly anabolic, meaning it promotes the growth of lean muscle tissue. This leads to increased muscle mass and improved physical appearance.

It is important to note that the effects and benefits of LGD-3033 may vary from person to person, and individual results typically differ. It is also important to follow proper dosage guidelines in order to get the best results.

LGD-4033 Effects and Benefits

LGD-4033, also known as Ligandrol, is a powerful Selective Androgen Receptor Modulator (SARM) that is highly regarded for its effects and benefits in the field of bodybuilding. This compound has gained popularity due to its ability to promote muscle growth, endurance, and recovery.

The specific effects and benefits of LGD-4033 include:

  • Muscle Growth: LGD-4033 has a strong anabolic effect, which means it can stimulate muscle protein synthesis and promote lean muscle mass development.
  • Endurance: Users of LGD-4033 often report increased stamina and endurance during workouts. This results in improved performance and the ability to push harder during training sessions.
  • Improved Recovery Speed: LGD-4033 has shown to have a positive impact on post-workout recovery by reducing muscle damage and inflammation. This has the potential to lead to faster recovery times and less muscle soreness.
  • Increased Strength: LGD-4033 has the potential to enhance strength gains, allowing users to lift heavier weights and perform intense workouts.

Overall, LGD-4033 has emerged as a popular choice among bodybuilders and athletes looking to enhance their physique and performance. Its effects on muscle growth, endurance, and recovery make it a valuable tool in achieving fitness goals.

LGD-3033 vs. LGD-4033 Side Effects 

When comparing the side effects of LGD-3033 and LGD-4033, it's important to note that both compounds belong to the class of Selective Androgen Receptor Modulators (SARMs) and have the potential to cause potential side effects, such as: 

  • May cause mild-to-moderate suppression of natural testosterone production.
  • Limited information is available, but preliminary studies suggest no significant liver toxicity.
  • Some users report mood swings, irritability, or aggression.
  • Limited information is available, further studies are needed to assess the impact on cardiovascular health.
  • Headaches, nausea, and other gastrointestinal disturbances have been reported in some cases.

Individual experiences with side effects vary, and the severity and likelihood of experiencing side effects may be influenced by factors such as dosage, duration of use, and individual sensitivity. 

LGD-4033 vs. LGD-3033 Bodybuilding Results

When it comes to bodybuilding, both LGD-3033 and LGD-4033 offer impressive results:


  • Promotes lean muscle gain: LGD-3033 is known for its ability to help users gain lean muscle mass rapidly. It enhances protein synthesis and nitrogen retention, leading to increased muscle growth.
  • Fat loss: LGD-3033 also aids in fat loss by boosting metabolism and facilitating the breakdown of adipose tissue.
  • Increased strength: Users often experience significant strength gains when using LGD-3033. It enhances muscular endurance and power output, allowing for more intense workouts.


  • Muscle growth: LGD-4033, also known as Ligandrol, is highly effective in promoting muscle growth. It increases lean muscle mass and improves overall body composition.
  • Endurance and recovery: LGD-4033 enhances endurance and reduces recovery time between workouts. This allows athletes and bodybuilders to train harder and longer, leading to improved performance.
  • Strength enhancement: LGD-4033 significantly improves strength levels, making it a popular choice among strength athletes.

Individual results vary, and factors such as diet, exercise regimen, and dosage play a significant role in achieving desired outcomes. 

Similarities and Differences Between 

When comparing LGD-3033 and LGD-4033, there are several similarities and differences between these selective androgen receptor modulators (SARMs):


  • Both compounds are SARMs, designed to target and stimulate androgen receptors in the body selectively.
  • LGD-3033 and LGD-4033 are known for their anabolic activity, meaning they promote muscle growth and enhance performance.
  • Both SARMs have been extensively studied and have shown promising results in terms of muscle development, bone strengthening, and combating muscle wasting.


  • LGD-3033 has a different chemical structure compared to LGD-4033, resulting in different binding preferences and potentially different effects.
  • LGD-3033 is believed to have a higher anabolic-to-androgenic ratio compared to LGD-4033, meaning it is more focused on muscle growth with potentially fewer androgenic side effects.
  • LGD-4033 has a longer half-life compared to LGD-3033, which means it remains in the body for a longer duration, requiring less frequent dosing.
  • The recommended dosage for LGD-3033 is typically lower compared to LGD-4033, which may affect the intensity and duration of the results obtained.

Final Verdict

In the final verdict, it is important to consider personal preferences, individual goals, and health considerations when choosing between LGD-3033 and LGD-4033.

Both LGD-3033 and LGD-4033 are powerful selective androgen receptor modulators (SARMs) that have shown effectiveness in muscle growth and performance enhancement. However, there are some key differences to consider.

Ultimately, the choice between LGD-3033 and LGD-4033 depends on individual goals, preferences, and health factors. Be sure to consult with a healthcare provider before adding a new supplement to your regimen in order to get the best results and avoid unwanted side effects. 


Can LGD-3033 and LGD-4033 be used together? 

There is limited information available about the effects of combining LGD-3033 and LGD-4033. It is recommended to consult with a healthcare professional before considering any stack or combination of SARMs.

Can LGD-3033 and LGD-4033 be stacked with legal steroids?

They can potentially be stacked with other legal performance-enhancing substances, but this should only be done under the guidance of a healthcare professional due to possible side effects and drug interactions.

How should LGD-4033 be dosed?

The recommended dosage of LGD-4033 is 5-10mg per day. It's advisable to start with a lower dose and gradually increase.

How should LGD-3033 be dosed?

The recommended dosage of LGD-3033 is 10-20mg per day. However, the dosage may vary based on individual needs and tolerance.

What is the main difference between LGD-3033 and LGD-4033?

The main difference is their potency. LGD-3033 is considered more potent, leading to more significant muscle gains.

Are LGD-3033 and LGD-4033 legal? 

The legal status of LGD-3033 and LGD-4033 may vary from country to country. It is essential to research and understand the regulatory laws surrounding these compounds in your specific location.

Where can I purchase LGD-3033 and LGD-4033?

These SARMs can be purchased from various online retailers. Ensure to buy from a reputable source to guarantee product quality and authenticity.

  1. Basaria, Shehzad et al. “The safety, pharmacokinetics, and effects of LGD-4033, a novel nonsteroidal oral, selective androgen receptor modulator, in healthy young men.” The journals of gerontology. Series A, Biological sciences and medical sciences vol. 68,1 (2013): 87-95. doi:10.1093/gerona/gls078
  2. Dalton, James T et al. “Selective androgen receptor modulators for the prevention and treatment of muscle wasting associated with cancer.” Current opinion in supportive and palliative care vol. 7,4 (2013): 345-51. doi:10.1097/SPC.0000000000000015
  3. Roch, Paul Jonathan et al. “Ostarine and Ligandrol Improve Muscle Tissue in an Ovariectomized Rat Model.” Frontiers in endocrinology vol. 11 556581. 17 Sep. 2020, doi:10.3389/fendo.2020.556581
  4. Sullivan, M L et al. “The cardiac toxicity of anabolic steroids.” Progress in cardiovascular diseases vol. 41,1 (1998): 1-15. doi:10.1016/s0033-0620(98)80019-4
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