MK-2866 vs LGD-4033: Which of These SARMs is Better?

MK-2866 vs LGD-4033: Everything you need to know

When it comes to SARMs, MK-2866 and LGD-4033 are two of the most popular options in the world of fitness and bodybuilding. 

Both of these compounds have gained attention for their muscle-building abilities, but the question remains: which one is better? 

In this article, we will delve into the similarities and differences between MK-2866 and LGD-4033, otherwise known as Ostarine and Ligandrol,(1) inspecting their origins, effects, and potential benefits. By understanding the facts, you will make an informed decision and choose the SARM that best fits your goals.

Introduction to MK-2866 and LGD-4033

MK-2866 and LGD-4033 are both SARMs (selective androgen receptor modulators) that have gained popularity in the fitness and bodybuilding community for their muscle-building and performance-enhancing properties. 

SARMs are a class of compounds that selectively bind to and activate androgen receptors in the body, leading to increased muscle mass and improved athletic performance without the negative side effects associated with anabolic steroids.

Overview of MK-2866

MK-2866, also known as Enobosarm or Ostarine, is a popular selective androgen receptor modulator (SARM) that is commonly used for muscle building and performance enhancement. One of its key uses is in the treatment of muscle wasting conditions, making it a valuable tool for those seeking to improve muscle mass and strength.(2)

The benefits of MK-2866 extend beyond muscle development. It has shown potential for enhancing bone health, making it a suitable choice for individuals looking to improve overall skeletal integrity. This SARM also aids in increasing endurance, which is helpful for athletes or fitness enthusiasts looking to improve their workout performance.

It is important to note that, while MK-2866 offers numerous benefits, it may also have potential side effects. Like other SARMs, MK-2866 can lead to mild testosterone suppression, meaning that individuals may experience a decrease in natural testosterone levels. However, this is typically less pronounced compared to anabolic steroids. Additionally, MK-2866 is well-tolerated and has a lower risk of liver toxicity than traditional steroids.

Overall, MK-2866 is highly regarded for its potential muscle-building properties, bone health benefits, and endurance improvement. As with any supplement or substance, it is important to consult with a medical professional before starting its used to ensure it aligns with personal goals and health considerations.

Overview of LGD-4033

LGD-4033, also known as Ligandrol, is a selective androgen receptor modulator (SARM) that is popular among athletes and bodybuilders due to its potential to increase muscle mass and strength gains. It is classified as a performance-enhancing substance and is often used to improve athletic performance and promote muscle growth.

LGD-4033 has shown promising results in increasing lean muscle mass and promoting muscle growth. It does so by binding to androgen receptors in the muscles, stimulating protein synthesis and promoting muscle hypertrophy.

Users of LGD-4033 often report significant improvements in strength and power. This can lead to enhanced athletic performance and the ability to lift heavier weights.

LGD-4033 has been known to aid in post-workout recovery. It can help reduce muscle soreness and increase the efficiency of the body's recovery process, allowing for faster muscle repair and growth.

It is important to note that LGD-4033, like any other SARM, has potential side effects. These can include testosterone suppression, liver toxicity, and mood changes. It is advisable to consult with a healthcare professional before starting any SARMs regimen to understand the potential risks and make an informed decision.

MK-2866 vs. LGD-4033 Effects and Benefits

When comparing the effects and benefits of MK-2866 and LGD-4033, both SARMs offer unique advantages for individuals looking to enhance their muscle building and performance capabilities.(1)

MK-2866 Effects and Benefits

MK-2866, also known as Ostarine or Enobosarm, is a highly regarded and popular selective androgen receptor modulator (SARM). It offers several impressive effects and benefits for users looking to enhance their muscle-building and performance capabilities.

  • Promotes Muscle Growth: One of the key benefits of MK-2866 is its ability to promote lean muscle mass. It works by selectively binding to androgen receptors in muscles, stimulating protein synthesis and muscle growth. This leads to an increase in muscle mass without the unwanted side effects commonly associated with anabolic steroids.
  • Healthy Joints: Joint health is another notable benefit of MK-2866. It has been found to have a protective effect on joints by reducing inflammation and increasing collagen synthesis. This can be particularly beneficial for individuals engaged in intense physical activities that put stress on their joints.
  • Enhanced Endurance: MK-2866 has been reported to improve endurance and stamina. Many users highlight its ability to enhance their cardiovascular performance, allowing for more intense workouts and longer durations of physical activity.

Overall, MK-2866 offers users the potential to experience significant improvements in lean muscle mass, endurance, and joint health. 

LGD-4033 Effects and Benefits

LGD-4033, also known as Ligandrol, is known for its significant effects on muscle growth and strength gains. Some of the specific effects and benefits of LGD-4033 include:

  • Rapid muscle gain: LGD-4033 is highly effective in promoting lean muscle mass growth. It helps increase muscle size and strength, making it a popular choice among athletes and bodybuilders.
  • Fat loss: LGD-4033 has shown potential in promoting your ability to lose fat when you're cutting, whilst also preserving muscle mass. This makes it an attractive option for those seeking to improve body composition.
  • Increased recovery speed: LGD-4033 aids in the recovery process by reducing muscle damage and inflammation. This allows individuals to train more frequently and recover faster between workouts.
  • Bone health: LGD-4033 has demonstrated the ability to increase bone density, making it beneficial for individuals dealing with conditions such as osteoporosis or muscle wasting.

It is important to note that with any performance-enhancing substance, potential side effects and individual response vary. 

MK-2866 vs. LGD-4033 Side Effects

When comparing the potential side effects of MK-2866 and LGD-4033, it is important to consider the following factors.

Side effects of MK-286:

  • Considered as having low liver toxicity
  • Minimal testosterone suppression, most users do not require post-cycle therapy (PCT)
  • No significant mood changes reported

Side effects of LDG-4033:

  • Moderate testosterone suppression may require PCT for some individuals
  • No significant liver toxicity reported in clinical studies
  • Potential for mood swings and irritability

Overall, Both MK-2866 and LGD-4033 are considered as having a favorable safety profile compared to traditional anabolic steroids. However, it is important to note that individual responses may vary, and it is recommended to consult with a healthcare professional before starting any SARMs regimen.

While MK-2866 has minimal testosterone suppression and is well-tolerated, LGD-4033 may cause moderate suppression in some individuals. This suppression may require post-cycle therapy (PCT) to restore normal testosterone levels.

In terms of liver toxicity, both compounds have shown low hepatotoxicity levels in clinical studies, with no significant liver damage reported. This makes them a safer option that traditional anabolic steroids. Mood changes are less common with MK-2866, whereas LGD-4033 has been associated with potential mood swings and irritability in some users.

It is important to remember to prioritize personal goals, consider health considerations, and seek professional advice before deciding which SARM is suitable for your specific needs.

LGD-4033 vs. MK-2866 Bodybuilding Results

When it comes to bodybuilding results, both LGD-4033 and MK-2866 have shown significant effects. 

LGD-4033, also known as Ligandrol, is well known for its muscle-building properties. It can lead to rapid muscle gain, making it popular among athletes and bodybuilders looking to enhance their physique. It improves strength and endurance, allowing individuals to push harder during workouts and lift heavier weights. Additionally, LGD-4033 has shown potential for fat loss, making it a versatile compound for body recomposition.

MK-2866, also known as Enobosarm or Ostarine, is favored for its ability to promote lean muscle mass. It is especially effective for individuals aiming to gain quality muscle while minimizing fat gain. MK-2866 also improves endurance, making it easier to perform longer and more intense workouts.

Another notable benefit is its positive impact on joint health, which is beneficial for athletes engaging in repetitive or high-impact activities.

Here's a summary of the bodybuilding results that are to be expected from LGD-4033 and MK-2866:


  • Perfect for bulking cycles due to its ability to promote rapid muscle gain
  • Improved strength and endurance
  • Promotes weight loss
  • Ability to inhibit the growth of cancer cells


  • Promotion of lean muscle mass
  • Ideal for cutting cycles due to its ability to burn fat
  • Increased endurance and performance
  • Positive effects on joint health

It's important to note that individual responses may vary, and results can be influenced by factors such as dosage, diet, training regimen and genetic predisposition. 

Professional advice and guidance are recommended when considering the use of SARMs for bodybuilding purposes.

Similarities and Differences Between MK-2866 and LGD-4033

There are some similarities and differences between MK-2866 and LGD-4033, two popular selective androgen receptor modulators (SARMs). When it comes to choosing between Ostarine vs Ligandrol, you will need to consider what sets them aside from eachother.


  • Fat loss: Both SARMs have the ability to burn fat whilst preventing muscle wasting.
  • Increased endurance: Both SARMs are known to increase strength and improve resistance training results.
  • Faster post-workout recovery times: Both SARMs are able to assist you in faster post-workout recovery, with healthier ligaments and joints that bounce back in no time.
  • A half-life of 24-hours: On average, both SARMs begin working in as little as 24-hours, showing swift results.
  • Cancer cell inhibition: Both have the potential to inhibit the growth of prostate cancer cells.(3)


  • Dosage: MK-2866 has a dosage of 10-30mg per day, whilst LGD-4033 has a dosage of 5-10mg per day.
  • Cycle length: MK-2866 has a recommended cycle length of six weeks, whilst the recommended cycle length of LGD-4033 is between eight weeks to ten weeks.
  • Targeted benefits: LGD-4033 is used to prevent muscle building and bulking, whilst MK-2866 is typically used for cutting cycles due to its ability to prevent muscle wasting.

Final Verdict

After our careful comparison of the effects, benefits, side effects, and bodybuilding results of MK-2866 and LGD-4033, the choice between the two will ultimately depend on your personal goals, health considerations, and professional advice.

If you are looking for lean muscle mass and improved endurance, then MK-2866 (Enobosarm/Ostarine) may be the better option for you. It is known for its ability to promote lean muscle growth and enhance endurance, making it suitable for athletes and individuals looking to improve their overall fitness levels.

However, if you want to gain muscle mass quickly and strength increases, then LGD-4033 (Ligandrol) has shown promising results in terms of muscle mass increase and strength gains. It may be a suitable choice for individuals aiming to bulk up and build significant muscle size and strength.

Lastly, if your fitness goals include burning body fat and improving recovery speed, then both MK-2866 and LGD-4033 have shown potential for fat loss and speeding up recovery. However, the extent of these effects may vary for each individual.

In conclusion, the choice between which is the better SARM, MK-2866 or LGD-4033, should be based on your specific needs, goals, and health considerations. Ask yourself the question of, do you want to increase your body mass? Or, do you want to shred? 

Remember to consult with a healthcare professional to provide valuable guidance and medical advice to ensure your safety throughout the process.


Are MK-2866 and LGD-4033 legal? 

Both MK-2866 and LGD-4033 are classified as selective androgen receptor modulators (SARMs). While they are not approved by the FDA for human consumption, they are still available for research purposes. It is important to note that the legal status of SARMs varies from country to country.

How long do the effects of MK-2866 and LGD-4033 last? 

The effects of both MK-2866 and LGD-4033 can vary depending on factors such as dosage, cycle length, and individual response. The effects of MK-2866 can be seen within a few weeks of starting the cycle and can last for several weeks after discontinuation. LGD-4033 is known for its long-lasting effects, with some users reporting benefits even after completing their cycle.

Can MK-2866 and LGD-4033 be stacked together? 

Yes, some users choose to stack MK-2866 and LGD-4033 for enhanced results. However, it is important to note that stacking SARMs can increase the risk of potential side effects. It is recommended to consult with a healthcare professional or experienced user before considering any SARMs stack.

Do MK-2866 and LGD-4033 require post-cycle therapy (PCT)? 

While MK-2866 is known to have minimal suppression of natural testosterone levels, LGD-4033 may require post-cycle therapy (PCT) to restore natural hormone levels. It is recommended to monitor hormone levels and consider PCT if necessary, especially after longer or higher dosage cycles.

Can women use MK-2866 and LGD-4033?

Yes, both SARMs can be used by women, but they should use a lower dosage than men due to their sensitivity to androgens.

Do MK-2866 or LGD-4033 work as an estrogen suppressive?

Neither MK-2866 (Ostarine) nor LGD-4033 (Ligandrol) are designed to work as estrogen suppressors. They are selective androgen receptor modulators (SARMs) intended to stimulate the androgen receptors in muscle and bone cells, leading to muscle growth. It's recommended to consult with a healthcare professional for estrogen suppression needs.

Which SARM is better for a beginner, MK-2866 or LGD-4033?

Both MK-2866 (Ostarine) and LGD-4033 (Ligandrol) are popular SARMs and can be suitable for beginners. However, MK-2866 is often preferred for those new to SARMs because it is considered milder and has a lower risk of side effects. As always, it's important to start with lower doses to assess tolerance. Always consult a healthcare professional before starting any new supplement regimen.

Where can I buy MK-2866 and LGD-4033?

These SARMs can be purchased from various online retailers, but ensure you choose a reputable source to avoid counterfeit products.

  1. Roch, Paul Jonathan et al. “Ostarine and Ligandrol Improve Muscle Tissue in an Ovariectomized Rat Model.” Frontiers in endocrinology vol. 11 556581. 17 Sep. 2020, doi:10.3389/fendo.2020.556581
  2. Dalton, James T et al. “Selective androgen receptor modulators for the prevention and treatment of muscle wasting associated with cancer.” Current opinion in supportive and palliative care vol. 7,4 (2013): 345-51. doi:10.1097/SPC.0000000000000015
  3. Nyquist, Michael D et al. “Selective androgen receptor modulators activate the canonical prostate cancer androgen receptor program and repress cancer growth.” The Journal of clinical investigation vol. 131,10 (2021): e146777. doi:10.1172/JCI146777
envelope-ostarstar-oclosecheck-square-obarslinkedinangle-downstar-half-empty linkedin facebook pinterest youtube rss twitter instagram facebook-blank rss-blank linkedin-blank pinterest youtube twitter instagram