LGD-4033 vs RAD-140: Comparing Benefits & Side Effects

ldg-403 vs rad-140

LGD-4033 vs RAD-140: Everything you need to know

Are you torn between LGD-4033 and RAD-140 for your next SARM cycle? 

Choosing the right compound can make a significant difference in achieving your muscle-building goals. In this blog post, we will compare LGD-4033 and RAD-140, highlighting their similarities and differences, to help you make an informed decision. 

Whether you're looking for consistent gains over long cycles or rapid mass-building results, this article will provide you with the factual data you need to choose the best SARM for your needs. Let's dive in and explore LGD-4033 vs RAD-140.

Introduction to LGD-4033 and RAD-140

LGD-4033 and RAD-140 are Selective Androgen Receptor Modulators (SARMs),(1) and both have demonstrated performance-enhancing properties. 

They work by selectively binding to androgen receptors in the body, leading to an increase in muscle mass and strength. Both LGD-4033 and RAD-140 are often compared due to their similar mechanisms of action and performance-enhancing benefits. 

They offer an alternative to traditional anabolic steroids, with potentially fewer side effects, such as liver toxicity or unwanted androgenic effects. 

Overview of LGD-4033

LGD-4033, also known as Ligandrol,(2) is a selective androgen receptor modulator (SARM) that is commonly used for its anabolic activity. It was initially developed to treat muscle wasting diseases and has gained popularity among athletes and bodybuilders for its performance-enhancing effects. LGD-4033 works by binding to androgen receptors in the muscles and bones, stimulating anabolic activity and promoting muscle growth.

One of the key benefits of LGD-4033 is its ability to increase lean muscle mass and strength gains. Users have reported significant improvements in their physique and athletic performance when using this compound. Additionally, LGD-4033 has been shown to increase bone density, which can be beneficial for individuals with osteoporosis or other bone-related conditions.

However, it's important to note that like other SARMs, LGD-4033 may have potential side effects. These can include testosterone suppression, mood changes, and hair loss. It's crucial to follow proper dosage guidelines and consult with a healthcare professional before using LGD-4033.

Overall, LGD-4033 offers a powerful tool for individuals looking to enhance their physical performance and overall physique. However, it's essential to weigh the potential benefits against the possible side effects and take appropriate precautions when using this compound.

Overview of RAD-140

RAD-140, also known as Testolone, is a selective androgen receptor modulator (SARM) that is currently being investigated for its potential therapeutic uses. 

Testolone's primary purpose is to stimulate androgen receptors in the body, which can have a number of effects. RAD-140 has shown promising results in promoting muscle growth and increasing lean body mass. It is often used by athletes and bodybuilders to enhance their performance and improve their physique.

RAD-140 has been found to have neuroprotective properties, meaning it has the potential to help protect and preserve brain cells.(3) This makes it a potential candidate for the treatment of neurodegenerative diseases such as Alzheimer's and Parkinson's.

Testolone, one of this supplement's active ingredients, has the potential to act as an alternative to testosterone replacement therapy, as it simulates the effects of testosterone in the body without the negative side effects associated with traditional hormone replacement therapies.

Overall, RAD-140 shows promise in various fields, including its potential applications in muscle growth, brain health, and testosterone replacement therapy. However, it is important to note that more research is needed to fully understand its benefits and potential side effects.

LGD-4033 vs. RAD-140 Effects and Benefits

When comparing the effects and benefits of LGD-4033 and RAD-140, both substances, also known as SARMs, offer unique benefits.

While both LGD-4033 and RAD-140 offer notable advantages in terms of muscle growth and performance enhancement, it's important to consider individual goals, preferences, and potential side effects when choosing which substance to use. 

LGD-4033 Effects and Benefits

LGD-4033, also known as Ligandrol, is a popular selective androgen receptor modulator (SARM) known for its potential benefits in muscle growth and recovery. It has gained attention among athletes and bodybuilders for its ability to promote lean muscle mass and enhance strength gains. Some of the key benefits of LGD-4033 include:

  • Increased lean muscle mass: LGD-4033 stimulates the androgen receptors in muscle and bone tissues, promoting anabolic activity and leading to increased muscle mass so you're able to bulk up.
  • Improved recovery times: LGD-4033 enhances the recovery process by promoting protein synthesis and reducing muscle damage, which helps athletes recover faster between training sessions.
  • Strength gains: Users of LGD-4033 often experience significant strength gains, allowing them to lift heavier weights and perform better during workouts.
  • Increased bone density: Studies have shown that LGD-4033 increases bone mineral density, making it potentially beneficial for individuals with bone-wasting diseases, such as osteoporosis.

It is important to note that while LGD-4033 has demonstrated promising effects in muscle growth and recovery, users should exercise caution and consult with a healthcare professional before using LGD-4033 to ensure its safe and appropriate use.

RAD-140 Effects and Benefits

RAD-140, also known as Testolone, is a powerful selective androgen receptor modulator (SARM) that offers a range of benefits for users. Here are the key effects and benefits of RAD-140:

  • Muscle Growth: RAD-140 is highly sought after by bodybuilders and athletes due to its ability to promote lean muscle mass. It works by binding to androgen receptors in the muscles, stimulating anabolic activity and enhancing protein synthesis. This leads to increased muscle size and strength gains.
  • Enhanced Endurance: RAD-140 has been shown to improve endurance and stamina, allowing users to push harder during workouts. This results in longer training sessions and greater overall fitness levels.
  • Cognitive Function: Another unique benefit of RAD-140 is its neuroprotective effects. It promotes brain health and enhances cognitive function, memory, and focus. This makes it appealing not only to athletes but also to individuals looking to optimize their mental performance.
  • Lean Body Mass: RAD-140 helps in reducing body fat while maintaining or even increasing lean body mass. This makes it a popular compound for those seeking to improve their body composition and achieve a more defined physique.

LGD-4033 vs. RAD-140 Side Effects

When comparing the side effects of RAD-140 and LGD-4033, it's important to note that both substances belong to the class of selective androgen receptor modulators (SARMs). While they are generally well-tolerated and have a lower risk of side effects compared to anabolic steroids, there are still some potential issues to be aware of.

LGD-4033 Side Effects:

  • LGD-4033 is has the potential to be a temporary testosterone suppressive. This has the potential to lead to a decrease in libido, mood changes, prostate health and fatigue.
  • Although LGD-4033 is relatively mild in terms of androgenic effects, some users may experience mild hair loss or acne.

RAD-140 Side Effects:

  • RAD-140 can also suppress natural testosterone production, which can lead to similar side effects as LGD-4033.
  • RAD-140 may have an impact on mood, potentially leading to irritability or aggression.
  • Some users may experience hair loss or thinning while taking RAD-140.

It's important to note that the severity and occurrence of side effects vary from individual to individual. To minimize the risk of side effects, it is recommended to follow proper dosing guidelines and consult with a healthcare professional before starting any SARMs cycle.

Additionally, it's important to note that long-term effects and potential risks of SARMs are still being studied, and more research is needed to fully understand their safety profile.

RAD-140 vs. LGD-4033 Bodybuilding Results

When it comes to bodybuilding, both RAD-140 (Testolone) and LGD-4033 (Ligandrol) are popular selective androgen receptor modulators (SARMs) known for their performance-enhancing properties.

RAD-140 is much more popular, due to its ability to increase lean body mass and strength gains. It helps in building muscle by stimulating the androgen receptors in the skeletal muscle and bone tissue, resulting in enhanced protein synthesis and muscle growth. Additionally, RAD-140 has been found to have neuroprotective effects and has the potential to be used in testosterone replacement therapy.

On the other hand, LGD-4033 provides anabolic activity and has been extensively studied for its potential in treating muscle-wasting diseases. Along with promoting lean muscle mass, this SARM also contributes to increased strength gains and improved bone density.

Whether you're using RAD-140 or LGD-4033, both offer significant benefits to bodybuilders aiming for performance enhancement:

  • Increased muscle mass gains
  • Improved strength and endurance
  • Enhanced recovery and muscle repair
  • Fat loss and improved body composition

It's important to note that individual results vary, as factors such as diet, exercise routine, PCT (post-cycle therapy) and genetics influence the outcomes. As with any performance-enhancing substances, it is crucial to understand and carefully monitor dosage, potential side effects, and adhere to proper cycling protocols.

Similarities and Differences Between LGD-4033 and RAD-140

LGD-4033 and RAD-140 are both SARMs commonly used for performance enhancement and muscle growth. While they have some similarities, there are also notable differences between the two substances.


  • Both LGD-4033 and RAD-140 are selective androgen receptor modulators, meaning they target specific androgen receptors in the body.
  • They both have potent anabolic effects, promoting muscle growth and increasing lean body mass.
  • Both substances have been shown to enhance strength, potentially leading to improved athletic performance.
  • They are both taken orally, which makes them convenient to use compared to other forms of performance-enhancing substances.


  • LGD-4033 (Ligandrol) has been primarily studied for its potential use in the treatment of muscle wasting diseases, as it has demonstrated anabolic activity in clinical trials. On the other hand, RAD-140 (Testolone) has shown neuroprotective effects and has been investigated in human trails for use in conditions such as Alzheimer's disease and testosterone replacement therapy.
  • While both substances contribute to a decrease of fat during a cycle, LGD-4033 is known for its potential positive impact on bone density, while RAD-140 increases cognitive functions and also provides improved endurance.
  • Side effects vary between the two substances. LGD-4033 has been associated with testosterone suppression, mood changes, and potential hair loss. Although RAD-140, on the other hand, has been reported to have fewer side effects, with minimal impact on hormonal balance.

Overall, LGD-4033 and RAD-140 offer different benefits and effects, and individuals should consider their specific goals and potential risks before deciding which is the better choice to use.

Final Verdict

In conclusion, both LGD-4033 and RAD-140 are powerful selective androgen receptor modulators (SARMs) that offer notable benefits for performance enhancement. However, there are some key differences to consider.

LGD-4033, also known as Ligandrol, is primarily recognized for its anabolic activity and ability to promote muscle growth. It is commonly used for treating muscle wasting diseases and has shown promising results in increasing lean muscle mass, enhancing strength gains, and improving bone density.

On the other hand, RAD-140, also known as Testolone, offers a more diverse range of benefits. In addition to promoting muscle growth, RAD-140 has neuroprotective effects and can potentially be used in testosterone replacement therapy. It has been studied for its positive impact on cognitive function, lean body mass, and endurance.

Overall, the choice between LGD-4033 and RAD-140 depends on individual goals and priorities. LGD-4033 is ideal for individuals primarily focused on muscle growth, while RAD-140 offers additional benefits for brain health.

It is important to consider potential side effects and consult with a healthcare professional before initiating any supplementation.


Are LGD-4033 and RAD-140 legal? 

As of now, both LGD-4033 and RAD-140 are considered research chemicals and are not approved by the FDA for human use, however they are legal in most countries. It is important to adhere to the regulations and laws in your country regarding the purchase and use of these substances.

What are the recommended dosages for LGD-4033 and RAD-140? 

The recommended dosage for LGD-4033 is typically between 5-10mg per day, while RAD-140 is usually taken at doses of 10-20mg per day. However, it is important to note that dosage recommendations can vary depending on individual factors and goals, as well as how often individuals go to the gym. 

Can LGD-4033 and RAD-140 be stacked with other substances? 

LGD-4033 and RAD-140 can be stacked with other SARMs or supplements for enhanced performance and muscle-building effects. Both have their own strengths and weaknesses, so you need to be very careful and consider the impact on our bodies when stacking. Typically, users shouldn't experience any severe side effects, but it's the better option is to consult with a healthcare professional or experienced user before starting any stack.

How long does it take to see results with LGD-4033 and RAD-140? 

Results vary depending on several factors, such as dosage, diet, exercise routine, and individual ability to tolerate the pros and cons of each substance. Some users start experiencing noticeable effects within a few weeks, while others may take longer. It is important to maintain consistency and be patient with the process to get the best results without adverse effects. 

Which is safer to use, LGD-4033 or RAD-140?

Both LGD-4033 and RAD-140 are considered relatively safe compared to traditional steroids, but they do come with potential side effects. The safety of these substances will largely depend on the dosage and the individual's overall health. Overall, the answer to whether one is better than the other depends on individual circumstances and lifestyle. It's important to note that these two SARMs provide less side effects than traditional anabolic steroids, and are still a safer alternative to synthetic steroid injections. 

Are there any long-term effects of using LGD-4033 or RAD-140?

As SARMs, LGD-4033 and RAD-140 are relatively new substances and long-term effects are not fully known. However, prolonged use may potentially lead to hormonal imbalance, liver damage, and other health complications. Always consult a healthcare provider before starting any new supplement regimen.

  1. Rosen, J, and A Negro-Vilar. “Novel, non-steroidal, selective androgen receptor modulators (SARMs) with anabolic activity in bone and muscle and improved safety profile.” Journal of musculoskeletal & neuronal interactions vol. 2,3 (2002): 222-4.
  2. Roch, Paul Jonathan et al. “Ostarine and Ligandrol Improve Muscle Tissue in an Ovariectomized Rat Model.” Frontiers in endocrinology vol. 11 556581. 17 Sep. 2020, doi:10.3389/fendo.2020.556581
  3. Jayaraman, Anusha et al. “Selective androgen receptor modulator RAD140 is neuroprotective in cultured neurons and kainate-lesioned male rats.” Endocrinology vol. 155,4 (2014): 1398-406. doi:10.1210/en.2013-1725
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