S23 vs RAD-140: Which SARM Is Best for You?

s23 vs rad-140

S23 vs RAD-140

Choosing the right SARMS is a daunting task, especially with so many options available. Two popular choices among bodybuilders and fitness enthusiasts are S23 and RAD-140. 

Each of these SARMs has its own unique benefits and potential side effects. In this article, we will compare S23 and RAD-140 to help you determine which one is best suited for your fitness goals. 

So, whether you're looking to bulk up or improve your cutting phase, keep reading to find out which SARMS is best for you.

Introduction to S23 and RAD-140

S23 and RAD-140 are both selective androgen receptor modulators (SARMs)(1) that have gained attention for their potential performance-enhancing effects. SARMs are a class of compounds that selectively bind to androgen receptors in the body, leading to an increase in muscle mass and strength. 

These compounds, including S23 and RAD-140, were initially developed for medical use with the aim of treating conditions such as muscle wasting and osteoporosis. 

However, due to their ability to promote muscle growth without the unwanted side effects commonly associated with anabolic steroids, they have also found popularity in the fitness and bodybuilding communities.

Overview of S23

S23 is a selective androgen receptor modulator (SARM) that is known for its potential benefits in muscle growth, bone health, and even as a male contraceptive. As a SARM, S23 has a high affinity for the androgen receptors in the body, which allows it to selectively target and stimulate muscle development without the undesirable side effects associated with anabolic steroids.

One of the primary benefits of S23 is its ability to promote lean muscle mass. It works by increasing protein synthesis, which is crucial for muscle growth and repair. S23 has also been found to promote fat loss, making it an appealing option for individuals looking to improve body composition.

In addition to its effects on muscle, S23 also has potential benefits for bone health. It has been found to increase bone mineral density and improve bone strength, which is especially beneficial for individuals at risk of osteoporosis or other bone-related conditions.

Interestingly, S23 has also been investigated for its potential as a male contraceptive.(2) It works by suppressing sperm production without affecting testosterone levels, making it a promising option for non-hormonal contraception methods.

Overall, S23 shows promise as a versatile compound that can have beneficial effects on muscle growth, bone health, and even contraception. However, it's important to note that further research is needed to fully understand its long-term effects and safety profile.

Overview of RAD-140

RAD-140, also known as Testolone, is a selective androgen receptor modulator (SARM) that has gained popularity in the fitness and bodybuilding community. It is known for its potential neuroprotective effects,(3) as well as its ability to increase muscle mass and strength. RAD-140 was initially developed to treat muscle wasting diseases, such as cancer cachexia and age-related muscle loss.

One of the key benefits of RAD-140 is its potential to promote muscle development without the androgenic side effects associated with traditional anabolic steroids. It selectively targets the androgen receptors in the muscle and bone tissues, leading to increased protein synthesis and enhanced muscle growth.

RAD-140 has also shown promising results in improving exercise performance and endurance. It does not have the same suppressive effect on natural testosterone production as other androgenic compounds, making it a popular choice among athletes and bodybuilders.

While RAD-140 offers numerous benefits, it is important to note that research on its long-term effects and potential side effects is still limited. Some potential side effects of RAD-140 include testosterone suppression, mood changes, and liver toxicity. It is advisable to consult with a healthcare professional before using RAD-140 or any other SARM.

Overall, RAD-140 offers a promising alternative to traditional anabolic steroids for individuals looking to enhance their muscle growth and performance while minimizing unwanted side effects.

S23 vs. RAD-140 Effects and Benefits 

When comparing the effects and benefits of S23 and RAD-140, it's important to consider their impact on muscle mass, strength, and endurance. These two popular SARMs both have their own unique bennefits and impact on your overall fitness routine.

S23 Effects and Benefits

S23 is a powerful selective androgen receptor modulator (SARM) that offers several benefits when it comes to bodybuilding and performance enhancement.

Some of the effects and benefits of S23 include:

  • Fat loss: S23 aids in fat loss by increasing the body's metabolism and promoting the use of stored fat as a source of energy during workouts.
  • Lean muscle mass: S23 is known for its ability to promote lean muscle growth. It helps increase protein synthesis, leading to the development of quality muscle tissue.
  • Increased bone density: Along with its muscle-building properties, S23 can also improve bone density, making it beneficial for individuals looking to strengthen their skeletal system.

It's important to note that S23 needs to be used with caution. It has potential side effects associated with its androgenic properties that must be considered and avoided through a suitable diet, excersize routine and post-cycle therapy (PCT).

RAD-140 Effects and Benefits

RAD-140, also known as Testolone, is a selective androgen receptor modulator (SARM) that has gained popularity among bodybuilders and athletes for its numerous benefits. 

  • Improved Cognition: One of the key advantages of RAD-140 is its ability to protect cognitive function. It has been shown to enhance memory and improve focus, making it potentially useful for individuals looking to improve their mental performance.
  • Muscle Growth: In terms of muscle development, RAD-140 is highly regarded for its anabolic effects. It promotes lean muscle mass gains by increasing protein synthesis and improving nitrogen retention in the muscles. This can lead to notable improvements in strength and overall muscle development.
  • Minimal Side Effects: RAD-140 also has a favorable anabolic to androgenic ratio, meaning it promotes muscle growth while minimizing androgenic side effects such as hair loss and acne. This makes it an attractive option for individuals seeking muscle gains without the undesirable androgenic effects commonly associated with anabolic steroids.

It's important to note that while RAD-140 has shown promising benefits, it is still a relatively new compound and more research is needed to fully understand its long-term effects and safety profile.

S23 vs. RAD-140 Side Effects 

When comparing the side effects of S23 and RAD-140, it's important to note that both compounds have the potential to cause adverse effects, although the severity and frequency may vary between individuals. Here are the key side effects associated with each compound:

S23 Side Effects:

  • Testosterone Suppression: S23 can suppress natural testosterone production, leading to hormonal imbalances. It is recommended to complete a proper post-cycle therapy (PCT) after using S23 to restore hormone levels.
  • Mood Changes: Some users have reported experiencing mood swings, irritability, and aggression while using S23. These effects are often temporary and subside once the compound is discontinued.
  • Liver Toxicity: Although S23 is not as hepatotoxic as some other compounds, it is still important to monitor liver function regularly during S23 cycles.

RAD-140 Side Effects:

  • Testosterone Suppression: RAD-140 also suppress natural testosterone production, although the extent of suppression may vary among individuals. As with S23, a PCT is recommended after using RAD-140.
  • Mood Changes: Some users have reported experiencing changes in mood, including irritability and mood swings, while taking RAD-140. However, these effects are mild.
  • Liver Toxicity: RAD-140 is not known to cause significant liver toxicity. However, it is always advisable to monitor liver function when using any performance-enhancing compounds.

It's important to consult with a healthcare professional or sports medicine specialist before using S23 or RAD-140 to fully understand the potential side effects and risks associated with these compounds.

RAD-140 vs. S23 Bodybuilding Results

When it comes to bodybuilding results, both RAD-140 and S23 have shown promising effects. Here's a comparison of what you can expect from each compound:


  • Muscle Gains: RAD-140 is known for its ability to promote lean muscle mass and enhance muscle development. Users have reported significant gains in muscle size and strength.
  • Workout Performance: RAD-140 improves workout performance by increasing endurance and stamina. Users often experience enhanced energy levels, allowing for more intense and productive training sessions.
  • Recovery Time: RAD-140 is believed to accelerate the recovery process, reducing muscle soreness and fatigue. This allows users to train more frequently and make faster progress.


  • Muscle Gains: S23 is renowned for its potent anabolic effects, promoting impressive muscle mass gains. It helps users achieve a more muscular and defined physique.
  • Workout Performance: S23 can enhance workout performance by increasing strength and power output. Users often experience improved overall performance and increased training capacity.
  • Recovery Time: S23 has been reported to improve the recovery process, reducing workout-related fatigue and promoting faster muscle repair. This allows for more consistent training and better results over time.

Overall, both RAD-140 and S23 contribute to significant muscle gains, improved workout performance, and quicker recovery. 

Similarities and Differences Between S23 and RAD-140 

When comparing S23 and RAD-140, it is important to consider their similarities and differences.


  • Both S23 and RAD-140 belong to a class of compounds known as selective androgen receptor modulators (SARMs) and work by selectively targeting androgen receptors in the body.
  • Both compounds have shown promise in enhancing athletic performance and promoting muscle growth.
  • S23 and RAD-140 have similar anabolic effects, meaning they can help increase lean muscle mass and strength.
  • Both compounds have been studied for their potential use in treating muscle wasting diseases.


  • S23 has been found to have a stronger androgenic effect compared to RAD-140, which means it may have a greater impact on increasing muscle mass and strength. This allows you to push harder at the gym than you would with RAD-140. 
  • RAD-140 has shown neuroprotective effects, making it beneficial for protecting and improving cognitive function.
  • S23 has potential as a male contraceptive due to its ability to suppress sperm production, while RAD-140 does not possess this characteristic. RAD-140 does provide moderate testosterone suppression, but this does not impact your sperm count in a contraseptive manner. 
  • RAD-140 has a higher anabolic to androgenic ratio compared to S23, indicating that it may have a more favorable profile for muscle development.

It is essential to note that both S23 and RAD-140 may have side effects, including testosterone suppression, mood changes, and liver toxicity.

Final Verdict

In the final verdict, when comparing S23 and RAD-140, several factors must be considered, such as the safety profile, efficacy and user preference.

Both S23 and RAD-140 have shown promising safety profiles in studies, with minimal side effects reported. However, it's important to note that long-term effects are not yet fully understood, and users should exercise caution and consult with healthcare professionals.

Additionally, both compounds have demonstrated significant effects in enhancing muscle mass, strength, and endurance. However, RAD-140 has an edge in terms of neuroprotective effects and potential benefits for individuals with muscle wasting diseases.

Personal preference may also play a role in choosing between S23 and RAD-140. Some individuals may prioritize specific benefits, such as increased bone density or cognitive protection, which could sway their decision.

It is important to consult with professionals, and consider individual goals and health conditions before adding a SARM to your fitness regimen. Additionally, adhering to recommended dosages and cycle lengths is crucial to minimize the potential for side effects and optimize results.


Are S23 and RAD-140 legal?

Both S23 and RAD-140 are considered research chemicals and are not approved for human consumption or use. It's important to note that laws regarding the purchase, possession, and use of these compounds may vary by country or region. Always consult local laws and regulations before purchasing or using S23 or RAD-140.

Can women use S23 or RAD-140?

S23 and RAD-140 are selective androgen receptor modulators (SARMs) that can potentially cause masculinizing effects in women. Therefore, it is generally advised that women avoid using these compounds to minimize the risk of virilization symptoms.

What is the recommended dosage for S23 and RAD-140?

Dosages for S23 and RAD-140 can vary depending on factors such as experience level, goals, and individual tolerance. However, the average daily dose for both RAD-140 and S23 is 20mg. It is recommended to start with a low dosage and gradually increase it if needed. It is essential to follow proper dosage instructions and consult with a healthcare professional for guidance.

Where can I buy S23 or RAD-140?

As research chemicals, S23 and RAD-140 are primarily available through online vendors that specialize in selling SARMs. It is important to source these compounds from reputable and trusted sources to ensure quality and purity.

How do S23 and RAD-140 work?

Both SARMs bind to androgen receptors in muscle and bone tissues, stimulating muscle growth and bone density. They are selective, meaning they target specific tissues, reducing unwanted side effects.

How do I use S23 and RAD-140?

Both SARMs are taken orally. The dosage varies depending on the individual's goals and tolerance. It's recommended to start with a lower dose and gradually increase.

Can I stack S23 and RAD-140?

Yes, they can be stacked for enhanced results. However, this should be done with caution due to the potential for increased side effects.

Do I need post-cycle therapy (PCT) after using S23 or RAD-140?

Yes, PCT is recommended after a cycle of either SARM to help restore natural hormone levels and mitigate side effects.

  1. Rosen, J, and A Negro-Vilar. “Novel, non-steroidal, selective androgen receptor modulators (SARMs) with anabolic activity in bone and muscle and improved safety profile.” Journal of musculoskeletal & neuronal interactions vol. 2,3 (2002): 222-4.
  2. Jones, Amanda et al. “Preclinical characterization of a (S)-N-(4-cyano-3-trifluoromethyl-phenyl)-3-(3-fluoro, 4-chlorophenoxy)-2-hydroxy-2-methyl-propanamide: a selective androgen receptor modulator for hormonal male contraception.” Endocrinology vol. 150,1 (2009): 385-95. doi:10.1210/en.2008-0674
  3. Jayaraman, Anusha et al. “Selective androgen receptor modulator RAD140 is neuroprotective in cultured neurons and kainate-lesioned male rats.” Endocrinology vol. 155,4 (2014): 1398-406. doi:10.1210/en.2013-1725
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