SR9009 vs GW501516: What's the Difference?

SR9009 vs GW501516: Everything you need to know

When it comes to enhancing performance and achieving fitness goals, it's important to consider the right supplements to support your journey. 

Two popular compounds in the fitness community, SR9009 and GW501516, have gained attention for their potential benefits. But what exactly sets these compounds apart? 

In this article, we'll explore the similarities and differences between SR9009 and GW501516, helping you make an informed decision about which one is right for you. So, let's dive in and discover the key distinctions between SR9009 and GW501516.

Introduction to SR9009 and GW501516

SR9009 and GW501516 are both performance-enhancing substances, also known as SARMs (Selective Androgenic Receptor Modulators),⁽¹⁾ and they are celebrated for their ability to provide benefits in fitness and bodybuilding.

Both SR9009 and GW501516 are commonly used by athletes and bodybuilders to improve performance and achieve their fitness goals. However, it's important to note that the use of these substances may come with certain risks and side effects. It's always recommended to consult with a healthcare professional before using any performance-enhancing substances.

Overview of SR9009

SR9009, also known as Stenabolic,⁽²⁾ is a synthetic compound that belongs to the family of Rev-ErbA agonists. It was developed by Professor Thomas Burris at the Scripps Research Institute. SR9009 is known for its potential benefits in improving metabolism, increasing endurance, and reducing inflammation.

SR9009 activates Rev-ErbA,⁽³⁾ which plays a crucial role in regulating metabolism and energy expenditure. By stimulating the production of mitochondria and regulating glucose metabolism, SR9009 can enhance stamina and endurance during physical activities.

SR9009 also has anti-inflammatory properties, which can aid in mitigating inflammation and promoting faster recovery. SR9009 works by binding to Rev-ErbA, a protein that controls gene regulation in the body. By activating Rev-ErbA, SR9009 regulates the expression of genes involved in metabolism, energy production, and inflammation.

Overview of GW501516

GW501516, also known as Cardarine,⁽⁴⁾ is a selective androgen receptor modulator (SARM) that was developed by GlaxoSmithKline in the 1990s. It was initially developed for the treatment of metabolic and cardiovascular diseases, but it gained popularity in the fitness and bodybuilding community due to its potential performance-enhancing effects.

GW501516 works by activating the Peroxisome proliferator-activated receptor-delta (PPAR-delta) in the body. This receptor plays a crucial role in regulating various metabolic processes, including lipid metabolism, glucose uptake, and insulin sensitivity,⁽⁵⁾

GW501516 has been shown to increase exercise capacity and endurance by stimulating the body's ability to utilize fatty acids for energy. This can lead to improved athletic performance and a decrease in fatigue. By increasing the body's metabolism of fatty acids, GW501516 helps promote fat loss and improve body composition.

GW501516 has been found to have anti-catabolic properties, meaning it has the potential to help prevent muscle breakdown and preserve lean muscle mass during periods of calorie restriction or intense exercise.

SR9009 vs. GW501516 Effects and Benefits

SR9009 and GW501516 are both popular compounds in the world of bodybuilding and performance enhancement. They offer unique effects and benefits, making them valuable tools for athletes and fitness enthusiasts.

SR9009 Effects and Benefits

SR9009, also known as Stenabolic, is a synthetic compound that has gained popularity among fitness enthusiasts and bodybuilders. Its primary mechanism of action is activating a protein called Rev-erbα, which plays a crucial role in regulating various metabolic processes in the body. The effects and benefits of SR9009 include:

• Enhanced endurance: SR9009 has been shown to increase stamina and endurance, allowing individuals to push harder during workouts and perform at a higher level for a longer duration.
• Increased energy levels: Users often report an increase in energy levels while taking SR9009, which contributes to improved performance and productivity.
• Improved fat metabolism: SR9009 helps to increase the metabolism of fats, leading to enhanced fat burning and weight loss.
• Enhanced muscle strength: SR9009 has been found to promote the growth of lean muscle mass and increase muscle strength.
• Improved cardiovascular health: SR9009 helps to improve cardiovascular health by reducing inflammation and improving lipid profiles.

It's important to note that further research is needed to fully understand the long-term effects and potential side effects of SR9009.

GW501516 Effects and Benefits

GW501516, also known as Cardarine, is a popular compound in the world of bodybuilding and endurance sports due to its impressive effects and benefits. Here are some of the key effects and benefits of GW501516:

• Enhanced Endurance: GW501516 is renowned for its ability to improve endurance levels significantly. It achieves this by activating the PPAR delta pathway, which increases the expression of genes involved in energy expenditure and enhances the utilization of fat for fuel. As a result, individuals experience increased stamina and resistance to fatigue during intense training sessions or endurance events.
• Fat Loss: GW501516 promotes the oxidation of fatty acids, leading to improved fat loss. By activating the PPAR delta pathway it enhances the breakdown of stored fat and increases the body's ability to use fat as an energy source. This can help individuals achieve a leaner and more defined physique.
• Muscle Preservation: While GW501516 is primarily known for its fat-burning properties, it also helps preserve muscle mass during periods of calorie deficit. It does this by increasing the expression of genes involved in muscle fiber formation and reducing muscle catabolism, resulting in a more defined and sculpted physique.
• Improved Cardiovascular Health: GW501516 has shown potential in improving cardiovascular health by increasing nitric oxide production, reducing inflammation, and promoting the growth of new blood vessels. This has positive implications for overall cardiovascular function and endurance performance.

It's important to note that GW501516 is still being researched and has not been approved for human consumption.

SR9009 vs. GW501516 Side Effects

When comparing the side effects of SR9009 and GW501516, it's important to note that both compounds have been extensively studied, but their long-term effects on humans are not fully understood. Here's a comparison of the potential side effects associated with each compound:

Side effects of SR9009:

• Limited studies have been conducted on SR9009 in humans, so the potential side effects are not well-documented.
• Some animal studies have reported changes in liver enzyme levels, but further research is needed to determine if this is relevant to humans.
• Other potential side effects may include increased heart rate, insomnia, and changes in lipid metabolism, but these effects have not been confirmed in human trials.

Side effects of GW501516:

• GW501516 has been associated with a variety of potential side effects, although these effects have been mostly observed in animal studies.
• Animal studies have suggested an increased risk of cancer, specifically in the liver, bladder, and stomach, but further research is needed to determine the relevance of humans.
• Other potential side effects may include changes in liver function, increased blood pressure, and changes in lipid metabolism, but these effects have not been extensively studied in humans.

Overall, both provide a different effect on your body and have their own set of potential side effects that must be considered when choosing between these two SARMs. 

SR9009 vs. GW501516 Bodybuilding Results

When it comes to bodybuilding, both SR9009 and GW501516 have gained popularity for their potential benefits.

SR9009 has been shown to improve endurance, increase metabolism, and enhance fat burning. It has the ability to activate the Rev-ErbA protein, which plays a role in regulating the body's circadian rhythm and energy metabolism. This activation leads to increased energy production and improved physical performance, making it an attractive option for bodybuilders looking to boost their stamina and endurance during workouts.

GW501516, on the other hand, is known for its ability to enhance fat burning and improve cardiovascular performance. It activates the PPAR-delta pathway, which increases the body's ability to burn fat for energy, while also improving insulin sensitivity and reducing inflammation. This can result in improved endurance, increased muscle definition, and enhanced overall athletic performance.

When it comes to bodybuilding results, both SR9009 and GW501516 provide noticeable benefits. Users may experience increased endurance, improved fat burning, and enhanced muscle definition. It's worth noting that these compounds should be used responsibly, and proper diet and exercise are still essential for achieving optimal bodybuilding results.

Similarities and Differences Between SR9009 and GW501516

SR9009 and GW501516 are both popular compounds used in the field of performance enhancement and bodybuilding, but they have some key differences:

Similarities between SR9009 and GW501516:

• Both are selective androgen receptor modulators (SARMs) that work by targeting specific androgen receptors in the body.
• They are both known for their potential effects on endurance, stamina, and fat-burning capabilities.
• Both compounds have been studied for their potential benefits in various medical conditions.

Differences between SR9009 and GW501516:

• SR9009 works by activating Rev-ErbA, a protein that regulates the circadian rhythm and metabolism, while GW501516 activates the peroxisome proliferator-activated receptor (PPAR) delta, which increases fatty acid oxidation.
• GW501516 is often touted for its endurance-enhancing effects, making it popular among athletes and bodybuilders. In contrast, SR9009 is more commonly associated with improving stamina and metabolism.
• SR9009 has shown potential benefits in increasing exercise capacity, reducing obesity, and improving cardiovascular health. GW501516, on the other hand, has been studied for its potential benefits in increasing endurance, improving lipid levels, and reducing inflammation.
• SR9009 may affect the circadian rhythm and metabolism, while GW501516 has not been shown to have any significant effects on these factors.

It's important to note that both compounds are subject to regulatory restrictions and are prohibited in competitive sports. It is recommended to consult with a medical professional before considering the use of these substances.

Final Verdict

After comparing the benefits, side effects, and impact on bodybuilding results of these two SARMs, the final verdict is that SR9009 and GW501516 are both powerful compounds with unique characteristics that can enhance athletic performance and bodybuilding results. However, there are some key differences to consider when choosing between the two.

The choice between SR9009 and GW501516 ultimately depends on individual goals and preferences. It is crucial to consult with a healthcare professional or a qualified trainer before considering the use of these compounds and to weigh the benefits against the potential side effects.

FAQs

1. Rosen, J, and A Negro-Vilar. “Novel, non-steroidal, selective androgen receptor modulators (SARMs) with anabolic activity in bone and muscle and improved safety profile.” Journal of musculoskeletal & neuronal interactions vol. 2,3 (2002): 222-4.↩
2. Dierickx, Pieterjan et al. “SR9009 has REV-ERB-independent effects on cell proliferation and metabolism.” Proceedings of the National Academy of Sciences of the United States of America vol. 116,25 (2019): 12147-12152. doi:10.1073/pnas.1904226116↩
3. Ikeda, Ryosuke et al. “REV-ERBα and REV-ERBβ function as key factors regulating Mammalian Circadian Output.” Scientific reports vol. 9,1 10171. 15 Jul. 2019, doi:10.1038/s41598-019-46656-0↩
4. Magliano, D'Angelo C et al. “Short-term administration of GW501516 improves inflammatory state in white adipose tissue and liver damage in high-fructose-fed mice through modulation of the renin-angiotensin system.” Endocrine vol. 50,2 (2015): 355-67. doi:10.1007/s12020-015-0590-1↩
5. Gan, Zhenji et al. “The nuclear receptor PPARβ/δ programs muscle glucose metabolism in cooperation with AMPK and MEF2.” Genes & development vol. 25,24 (2011): 2619-30. doi:10.1101/gad.178434.111↩